DNAimpact™ is a unique program offered through your benefits program. It’s designed with you in mind. With a simple at-home saliva test, our trusted lab partner can analyze your genetic information and give you insights that help guide you and your healthcare providers in making the best decisions about your care. This approach is often called personalized—or precision—medicine, because it means not just prescribing “the usual”, but prescribing what will work best with your DNA and your body..

You are eligible for DNAimpactRx because you meet the criteria included in your benefits program. Once you enroll, your eligibility typically continues for as long as you are covered under your current health plan.

If you have questions about your eligibility, our InformedDNA Patient Support team is here to help at (888) 526-3601 or patientsupport@dnaimpact.com.

The DNAimpact™ program offers different options for personalized education and genetic testing. DNAimpactRx is the option selected by your sponsor, and it focuses on pharmacogenomic testing. This type of test looks at your genes to understand how your body processes certain medications, helping your providers choose the safest and most effective treatments for you.

DNAimpactRx is part of the larger DNAimpact™ program. It’s all about the impact of your DNA on your health—using your genetic information to help you and your healthcare providers choose medications that work best for you, so every decision about your medications is as informed as possible. You’ll get an at-home saliva test kit to send to our lab partner. Once your genes are analyzed, you’ll receive a personalized report showing how certain medications may or may not be a good fit. You can also review your results with one of our pharmacists through a telehealth visit.

The program is offered as a part of your benefits program, and it’s available to you at no cost.

Our genes are made of DNA, and in the same way that DNA influences traits like eye color or hair color, DNA also affects how our bodies respond to medications. These results apply to medications you may be taking now, and medications you could be prescribed in the future.

That’s where pharmacogenomic testing comes in. This test looks at your genes to see how your body processes certain medications and how you are likely to respond to those medications. Will the medication work well for you? Will it cause side effects? Because everyone processes medications in their own way, the results can help your doctor pick the right medications and doses that are most likely to work for you—reducing side effects and making treatment more effective. Think of your DNA as a personalized guide for safer, smarter prescribing.

Check your benefit details to see what’s included. In some cases, family members may also be able to use the program.

This test looks at how your body processes and responds to different types of medications like blood thinners, pain relievers, cancer treatments, epilepsy drugs, as well as medications for mental health, heart, and other conditions. It also checks for medications that could cause a rare but serious “allergic-type” reaction in some people. These reactions happen when the immune system overreacts to a drug and can lead to severe rash, fever, organ problems, or even life-threatening skin conditions. By spotting certain genetic markers in your DNA ahead of time, pharmacogenomic testing helps your provider avoid medications that might cause trouble and find safer options that are a better fit for you.

No—it would not be safe to change your medications on the spot and this program doesn’t have access to all of your health information. As part of the program, a pharmacist consult is available to you at no cost. Following this consult, your provider will receive your personalized medication action plan with recommendations for them to consider along with your other health information to make the best decisions for you. Any actual changes to your prescriptions will be made directly by your healthcare provider. In the event you do not have a provider, you will receive a personalized DNAimpactRx Report and the medication action plan will be available for future providers.

Your healthcare provider can certainly order pharmacogenomic testing on their own. But through this program, the testing is covered at no cost to you. If your provider orders it separately, it may not be covered by your health plan, or you may have copays or other costs. Another key difference is that this program provides the opportunity to meet with an expert in pharmacogenomics who can review your genetic results alongside your medications—something your provider may not be able to offer.

No—this test won’t tell you about your risk for conditions like heart disease or cancer. It’s only focused on genes that affect how your body processes medications. Your test covers not just the medications you’re taking now, but also others you might need in the future—so you will already have the information ready if those medications are ever considered for you.

No, this test will only provide information about how your genes affect your response to specific medications.

If your test shows a medication may not work well for you, it doesn’t tell us for sure whether your family members might also carry the same gene change. This is because pharmacogenomics is complicated and different for each person. What we do know is that anyone can benefit from pharmacogenomic testing to learn which medications will or won’t work best for them now or in the future. So for your family members, especially those currently taking medications, it may be worth asking their provider whether testing could help them too.

Pharmacogenomic testing is very safe. The test itself is quick and easy. The most important things to keep in mind are how the information is used and what it might mean for your medication management. These are a few items to remember:

• The sample is usually collected with a saliva kit, so there is no pain or medical risk involved. However, it may take a little time to collect the amount of saliva needed.
• The test has limits. It looks only at specific genes and certain medications, so it may not answer every question you have about how your body responds to treatment. It’s a valuable tool, but it’s just one part of the bigger picture and does not replace your provider’s medical judgment.
• Your genetic information is unique to you, and we take your privacy seriously. We use strong security measures and follow strict privacy rules to keep your data protected every step of the way.

For more information on your rights and our responsibilities regarding your private health information, please read our Notice of Privacy Practices and Data Security policies.

Joining the program is completely up to you—it’s optional. If you decide not to participate, everything stays the same. Your decision will not affect your job, your relationship with your employer, or your health plan benefits in any way.

“Informed consent” means you fully understand the facts, benefits, and possible risks of something—like genetic testing—before you agree to it. Before your test kit is sent, you’ll be asked to review and sign an Informed Consent Form. This form gives you the key information you need to make a confident decision, including:

• What the test is and what it can (and can’t) tell you
• Any potential risks or limitations
• How your data will be stored and protected

We encourage you to read the consent form carefully and ask any questions you might have. If you’d like to talk with a genetic specialist before deciding, our InformedDNA Patient Support team is here to help at (888) 526-3601 or patientsupport@dnaimpact.com.

No, we’ll take care of ordering the test for you. With your permission, once your results are ready, we will send the information and recommendations to your provider to consider in making any changes to your medications.

• Check your email – Keep an eye out for the invitation from your program sponsor.
• Click the enrollment link – This will take you straight to the DNAimpactRx site, where you’ll enter a few quick details to get started.
• Provide informed consent – Review the key information and sign the consent form.
• Complete your profile – Tell us about your current medications, healthcare providers, and answer a few short health and lifestyle questions that will help us interpret your results and communicate with your healthcare providers.

Please complete these steps so we can send your testing kit.

• Collect your saliva sample – follow the simple step-by-step instructions provided. Place your sample in the test kit box, seal it, and drop it in any U.S. Postal Service mailbox. Your kit is already addressed to the lab and postage-paid.
• Learn while you wait – While your results are on their way, visit the DNAimpactRx site to explore easy-to-understand information about this testing and pharmacogenomics.

After you mail your saliva sample in the pre-paid envelope, it goes to our trusted partner lab. They test your DNA for specific genetic changes and create a technical report. That report is then securely sent to InformedDNA so we can prepare your personalized results and recommendations for your healthcare provider to consider.

If you lose or misplace your test kit, don’t worry–just call InformedDNA’s Support Care team at (888) 526-3601 or patientsupport@dnaimpact.com and we’ll help get a replacement to you right away.

The entire process usually takes about 4-6 weeks. Once the lab receives your saliva sample, it typically takes up to 4 weeks to extract and analyze your DNA. We’ll notify you as soon as your results are ready.

When you sign up for the program, you’ll choose which healthcare provider(s) you want to receive this information. We encourage you to share the names of all healthcare providers who have or may prescribe any medications for you. Our genetics experts will partner with you and your providers to make sure everyone stays informed. Your providers will be notified when you enroll and again once your testing is complete. They’ll also have access to all of your reports, which can help guide medication choices and any dose adjustments that may be needed.

When your results are ready, you’ll get an email with instructions to log in to your secure portal. Once you’re in, you can explore your results through easy-to-read information and icons and download or print your report.

This consult is simply a personal conversation with a pharmacogenomics expert, usually over the phone or on your computer. During this call, you’ll go over your results, get answers to your questions, and learn what your results might mean for your medications and care.

Once you return a test kit, authorized laboratory professionals can access your sample to perform the test and generate results. Authorized members of the InformedDNA team (employees or contractors) involved in your care can access your health profile, medication history, and results. Your results may also be shared with the healthcare providers you list, your pharmacy benefits manager, and other healthcare entities and professionals involved in your care to support coordination of care, payment, program operations, and medication decisions. Your information is protected under applicable privacy laws. It will not be released to others without your written permission, unless required by law. In some cases, data may be used for internal research or program improvement. Any data shared by InformedDNA is required to be de-identified, so that no information disclosed can be used to identify you. De-identifying data means that personal details such as your name and contact information are removed before sharing.

The Genetic Information Nondiscrimination Act (GINA) prohibits discrimination by health insurance plans and employers based on genetic information. “Genetic information” is defined as: Your genetic test results, Your relatives’ genetic test results (up to and including fourth-degree relatives), and/or information about family history of any disease or disorder. Information about your participation in research that includes genetic testing, counseling, or education is also protected.

The lab will use your sample only for testing and, if needed, to confirm your results. After that, your saliva sample is destroyed—usually within 90 days—so it isn’t saved or stored once testing is complete.

At any point in the process, if you have questions, need assistance or are unsure what to do, InformedDNA’s Support Care team is ready to help. Simply call (888) 526-3601 or email to patientsupport@dnaimpact.com.